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Systemic Lupus Erythematosus (SLE) is rated by the U.S. Department of Veterans Affairs under DC 6350 of 38 CFR § 4.88b, DC 6350 across 3 severity tiers (10% / 60% / 100%). Service connection requires (1) a current diagnosis, (2) an in-service event, injury, or exposure, and (3) a medical nexus opinion linking the two under 38 C.F.R. § 3.303. This condition is frequently rated as secondary to Lupus Nephritis or Pericarditis under 38 C.F.R. § 3.310.
Chronic autoimmune disease where the immune system attacks healthy tissue, causing inflammation across multiple organ systems (skin, joints, kidneys, heart, lungs, brain). Characterized by exacerbations ("flares") and remissions. More common in women, especially women of color. May develop after viral infections, certain medications, or environmental triggers including burn-pit exposure or sun exposure.
Rating criteria text quoted verbatim from 38 C.F.R. § 4.88b (Infectious diseases, immune disorders, and nutritional deficiencies). Source verified 2026-05-17 by ClaimRecon Editorial Team against the Cornell Law CFR mirror; eCFR.gov is the authoritative government source.